Over 334,000,000 doses of the Moderna, Pfizer, and Johnson & Johnson vaccine have been administered since December of 2020. Side effects are common and have been widely reported. In a prospective observational study conducted using data from the COVID Symptom study application, 22% of 28,207 patients reported systemic adverse effects after receiving the second dose of the Pfizer BioNTech (BNT162b2) vaccine