In the 1800s small pox killed 100s of thousands. After the vaccines it killed 200 million+:

https://en.m.wikipedia.org/wiki/History_of_smallpox

Prior to the first successful vaccine for smallpox in 1959 there had been a long questionable series of vaccines that were problematic:

https://leadstories.com/hoax-alert/2021/06/fact-check-raggedy-ann-and-andy-dolls-were-not-created-to-symbolize-children-who-died-from-vaccinces.html

The vaccines prior to 1959 and the who's rollout of a higher quality version, vaccines were often deadly, as in the case of the raggedy Anne creator dedicating his books to the memory of his daughter (the books can be found on archive.org and dedication is clear in those texts). Not the doll itself but the doll was used in later anti Vax efforts by the author.

In the 1800s small pox killed 100s of thousands. After the vaccines it killed 200 million+:

https://en.m.wikipedia.org/wiki/History_of_smallpox