This is a comprehensive investigation of the pathophysiological changes, including detailed immunological alterations in people after COVID-19 vaccination. Results indicated that vaccination, in addition to stimulating the generation of neutralizing antibodies, also influenced various health indicators including those related to diabetes, renal dysfunction, cholesterol metabolism, coagulation problems, electrolyte imbalance, in a way as if the volunteers experienced an infection. scRNA-seq of PBMCs from volunteers before and after vaccination revealed dramatic changes in immune cell gene expression, not only echoing some of the clinical laboratory measures but also suggestive of increased NF-κB-related inflammatory responses, which turned out to be mainly taking place in classical monocytes. Vaccination also increased classical monocyte contents. Moreover, the gene set positively contributing to MVS scores, also known to be associated with severe symptom development, was highly expressed in monocytes. Type I interferon (IFN-α/β) responses, supposedly beneficial against COVID-19, were downregulated after vaccination. In addition, the negative MVS genes were highly expressed in lymphocytes (T, B, and NK cells), yet showed reduced expression after vaccination. Together, these data suggested that after vaccination, at least by day 28, other than generation of neutralizing antibodies, people’s immune systems, including those of lymphocytes and monocytes, were perhaps in a more vulnerable state.
The analyses presented in this study, particularly, scRNA-seq of PBMCs had not been performed for previous vaccine evaluations, whether the changes in immune system function-related genes were COVID-19-specific or could be generally applied to other vaccines or other types of COVID-19 vaccines remained to be determined. However, these types of detailed analyses should be overall beneficial to vaccine development and applications. Our study postulates that it is imperative to consider the potential long-term impact of vaccination to certain medical conditions34 or to general human health
Pretty much an interesting side issue which is not particularly relevant at this point. The vaccine tested in this study is not approved for use in Canada or the US, the trial had only eleven participants, and they can't tell if the findings apply to the approved vaccines.
As the authors state: "whether the changes in immune system function-related genes were COVID-19-specific or could be generally applied to other vaccines or other types of COVID-19 vaccines remained to be determined."
Perhaps they can convince some funding agency to support further research.
That's the point. We don't know the long term consequences of vaccinating people, and therefore it is an experiment. We know the vaccines are not safe in the short term, no matter how much you want it to be otherwise. This experiment shows that we do not know the long term consequences of vaccinating people with these experimental vaccines.
Our study postulates that it is imperative to consider the potential long-term impact of vaccination to certain medical conditions34 or to general human health
Who will be held accountable if it turns out that the vaccines have adverse long term effects?
NUREMBERG here we come!
It makes sense if you put it that way. The long-term effects of our use of technology are equally unknown, although the pollution of our air, water and soil has already provided some unpleasant surprises.
With all that going on every day everywhere it seems odd to find fault with some chemistry that keeps people out of the hospitals.
So you say, with no supporting links. As far as I know a lot of the people in the ICUs are there with covid. Do you know of any ICU patients who are there because of their covid vaccine.
The one with 11 people in it?
In your dreams. The clinical trials are over and the approved vaccines are recognized as safe. https://duckduckgo.com/?q=covid+and+the+Nuremberg_Code&t=h_&ia=web
One result: "The Nuremberg Code specifically addresses experimentation; COVID-19 vaccines aren’t experimental, and therefore, don’t violate the Code"
I can see the sweat on your brow from here. Better ask for a pay raise to keep correcting the record. Also make sure there's a clause in your contract that you will not be held liable when the NUREMBERG trials begin.
Be sure to read up on the subject before betting anything on it.
https://duckduckgo.com/?q=covid+and+the+Nuremberg_Code&t=h_&ia=web